Port Graham is a traditional Sugpiaq village with a fishing and subsistence lifestyle and a population of around 178. Many of the Native residents are Sugpiaq. The village is located at the southern end of the Kenai Peninsula on the shore of Port Graham.

Port Graham was originally a cannery and wharf, as reported by the U.S. Geological Survey in 1909. A post office operated between 1938 and 1961. A pink salmon hatchery became operational in 1991.

A new $4.5 million fish cannery opened on June 19, 1999. The former plant and salmon hatchery were destroyed by fire in January 1998. Locals organized funding to rebuild the facilities because insurance covered only part of the loss. The cannery provides seasonal employment for 70 Port Graham and Nanwalek residents. The hatchery was rebuilt in a separate but adjacent building during the summer of 1999. Red salmon fry are raised for area lakes, and pink salmon are raised for the cannery.